https://www.ceesdekker.net - An Overview
https://www.ceesdekker.net - An Overview
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Making use of single-molecule optical and AFM imaging and drive-spectroscopy approaches, we find to unravel the mechanistic elements of the structure and dynamics of chromosomes. Our exploration passions consist of:
It had been only during the 1990s while, when nanotechnology had State-of-the-art to a stage where solitary molecules can be manipulated, that the initial experimental equipment began to seem.
[Laughs] ‘It absolutely was definitely a great risk! At some time, I had been properly mindful that it could go Mistaken and that I could turn out to be much less thriving, but I just disregarded that. Curiosity has generally been my strongest driving pressure. And by chance it all labored out.’
Non-equilibrium folding of unique DNA molecules recaptured as much as one thousand situations inside a sound point out nanopore
2010, designed a different way (‘wedging transfer’) to govern nanostructures; initial report of DNA translocation by means of graphene nanopores; and recognized hybrid nanopores by directed insertion of α-hemolysin into stable-point out nanopores
Microbiology has only existed for just a century, because we started to study micro-organisms a lot more significantly. I believed nanobiology was an proper phrase, due to the fact all molecular Organic appropriate interactions happen with the nanoscale: a protein is a number of nanometres in dimensions, DNA is 2 nm thick.’
Lots of related developments followed, where our team founded different transistor variants such as single-electron transistors at area temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled several transistors into tiny proof-of-principle electronic circuits.
Instance (one) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is demonstrated in grey, the rim on the pore is highlighted in red, and also a 3D rendering on the movement in the DNA rod is exhibited.
The rotors harness Electricity from a nanoscale h2o and ion circulation that's created by a static chemical or electrochemical likely gradient within the nanopore, which are recognized by way of a salt gradient or applied voltage, respectively. These synthetic nanoengines self-organize and run autonomously in physiological situations, suggesting strategies to constructing Electrical power-transducing motors at nanoscale interfaces.
Resolving the phase measurement in condensin-driven DNA loop extrusion identifies ATP binding because the step-generating process
‘The concept there is such a point being a commencing, a major bang, is currently an interesting signpost to take into account that there was a creator. But additional frequently, and on The premise of pure rationality, I also get there in a Christian interpretation of truth. An atheistic worldview is a naturalistic worldview: fundamentally, you will find only atoms and organic forces that we will measure.
2006, initially demonstration of molecular sorting in a very lab over a chip employing biomotors; discovery of nanobubbles in reliable-condition nanopores; and very first estimate of electrokinetic Power conversion inside a nanofluidic channel
Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of just one wire bridging two electrodes
The biophysicist from Delft – who has been one of the most cited experts during the Netherlands For many years – takes his cees dekker duty to contribute towards the clarification and popularisation of his function at the border of physics and biology particularly severely and routinely appears from the media; if not to talk about his get the job done, then about the relationship between science and his Christian religion.